Molecular Basis of Cancer
Several MMG research groups are investigating the molecular etiology of cancer induced by tumor viruses as well as the alterations in signaling pathways associated with oncogenic transformation. Specific projects are focused on the role of microRNAs in HPV-associated cervical cancer, the KSHV and MCV human tumor viruses, and protein-tyrosine kinases as molecular targets for cancer therapy.
Associated Labs
Moore Lab
We study 1) Kaposi’s sarcoma-associated herpesvirus (KSHV), the viral cause of Kaposi’s sarcoma, 2) Merkel cell polyomavirus (MCV), the viral cause of Merkel cell carcinoma and 3) methods to search for undiscovered human tumor viruses. Learn more>
Shair Lab
The Shair lab studies the molecular mechanisms of cancer induced by this latent virus with the purpose of defining how these mechanisms contribute to the oncogenic and metastatic properties of EBV-associated diseases. Learn more>
Smithgall Lab
This laboratory research is focused on non-receptor protein-tyrosine kinase structure, function, and inhibitor discovery. Interest lies specifically in the Src, Abl and Fes kinase families, which were originally discovered in the context of avian transforming retrovirus many years ago. Learn more>
Thomas Lab
Our research program focuses on signaling pathways that integrate membrane traffic with the regulation of homeostasis and the onset of disease. These studies were grounded by our identification of the proprotein convertase furin, which is the first member of a family of secretory pathway-localized endoproteases that catalyze the activation of bioactive proteins and peptide hormones. Learn more>
Associated Publications
Youngner Lecture
Save the Date! Youngner Symposium -- May 3-4, 2023
