University of Pittsburgh

Patrick S. Moore, MD, MPH

Distinguished Professor





	
	


			

		Dr. Moore	
		

		

	
Contact

    		

		psm9@pitt.edu	
		

		
			

		412-623-7718	
		

		
	
	
			

		Fax: 
		412-623-7715	
		

	    

    
    
   
    
   
    
    		

		
1.8C Hillman Cancer Center
5117 Centre Avenue
	
		

	    
    
   
   
   
   
   
   
    
    
	
	
	
			

		Pittsburgh, PA 15213-1862	
		

		
		
	



	
Education
	
	

	
MD, University of Utah 
MPH in Epidemiology, University of California, Berkeley 
        

              
   
  
 
 	
Research Summary
	
	

	
Our lab investigates viral
causes of human malignancy and identifies new cancer-causing viruses
using digital transcriptome subtraction. We currently focus on two
agents we have discovered, KSHV (the viral cause of Kaposi’s sarcoma)
and MCV (the viral cause for most Merkel cell carcinomas). We focus on
the basic molecular virology of transformation as well as develop
assays that have clinical value in detecting tumor virus infection. Most recently, we have characterized MCV mutations that truncate the
MCV T antigen helicase to disable viral replication in tumors. We have
also developed MCV T antigen monoclonal antibodies and virus-like
particle serologic tests that allow us to screen patients and tissues
for MCV infection. Additional research involves the search for
potential KSHV vaccine candidates through analysis of latent KSHV
protein immune processing.  
	
	




  
 
 
 
 
 
 
 
         
        
        
        
        
        
        
        
        
 
 
   
   
















        









	
Research Lab Affiliation
	
	

	Moore Lab	
	













	
Publications
	
	

	
Kwun, H.J; Chang, Y. and Moore, P.S. (2017) Protein-mediated viral latency is a novel mechanism for Merkel cell polyomavirus persistence. Proc Natl Acad Sci USA. 114: E4040-E4047. |  View Abstract
Velasquez C, Cheng E, Shuda M, Lee-Oesterreich PJ, Pogge von Strandmann L, Gritsenko MA, Jacobs JM, Moore PS and Chang Y. (2016) Mitotic protein kinase CDK1 phosphorylation of mRNA translation regulator 4E-BP1 Ser83 may contribute to cell transformation. Proc Natl Acad Sci USA. 113: 8466-8471. |  View Abstract
Toptan, T; Yousem, S.A; Ho, J; Matsushima, Y; Stabile, L.P; Fernandez-Figueras, M.T; Bhargava, R; Ryo, A; Moore, P.S. and Chang, Y. (2016) Survey for human polyomaviruses in cancer. JCI Insight. 1.  |  View Abstract
Why do viruses cause cancer? Highlights of the first century of human tumour virology. Nat Rev Cancer. 10: 878-889. |  View Abstract
Shuda, M; Feng, H; Kwun, H.J; Rosen, S.T; Gjoerup, O; Moore, P.S. and Chang, Y. (2008) T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus. Proc Natl Acad Sci USA. 105: 16272-16277. |  View Abstract
Feng, H; Shuda, M; Chang, Y. and Moore P.S. (2008) Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science. 319: 1096-1100. |  View Abstract
Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV. Science. 274: 1736-1744. |  View Abstract
Chang, Y; Cesarman, E; Pessin, M. S; Lee, F; Culpepper, J; Knowles, D. M; and Moore, P. S. (1994) Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science. 266: 1865-1869. |  View Abstract