Molecular Virology
Understanding the molecular basis of viral interactions with their hosts requires a more complete picture of virus structure and regulation at the molecular level. Groups in this focus area are investigating the regulation of viral gene expression, mechanisms of viral capsid assembly and DNA packaging, alterations in host cell signaling by HIV accessory factors, virus entry into host cells, as well as engineering viral vectors for the analysis of host cell function.
Associated Labs
DeLuca Lab
Repression and activation of persisting HSV genomes: Herpes simplex virus can undergo either a productive infection, where all the viral genes are expressed culminating in the production of progeny virus and cell death, or it can enter a latent state, which is characterized by the relative lack of viral gene expression, genome persistence, and cell survival. Learn more>
Glorioso Lab
Dr. Glorioso’s most recent research has focused on (i) the design and application of HSV gene vectors for exploring the molecular events that occur in sensory afferents that are involved in the transition from acute to chronic pain. Learn more>
Homa Lab
Research in our lab is focused on understanding the mechanism of herpesvirus capsid assembly and DNA packaging. Learn more>
Lakdawala Lab
Our lab studies the molecular properties contributing to the epidemiological success of influenza A viruses to better predict future pandemics. There are two main areas of research in my lab 1) exploring the intracellular dynamics of influenza viral RNA assembly and 2) defining the viral properties necessary for efficient airborne transmission of influenza viruses. Learn more>
Shair Lab
The Shair lab studies the molecular mechanisms of cancer induced by this latent virus with the purpose of defining how these mechanisms contribute to the oncogenic and metastatic properties of EBV-associated diseases. Learn more>
Xiao-Qu Lab
Our primary research interests include the study of signaling transduction pathways in immunity and tumorigenesis, particularly NF-kB, as well as the molecular mechanisms underlying the type-1 human T cell leukemia virus (HTLV-I) mediated T cell transformation for disease prevention and therapeutic purposes. Learn more>