University of Pittsburgh

Sidney M. Morris Jr., PhD

Professor Emeritus





	
	


			

		Dr. Sid Morris	
		

		

	
Contact

    		

		smorris@pitt.edu	
		

		
			

		412-626-0558	
		

		
	
	
	    

    
    
   
    
   
    
        
    
   
   
   
   
   
   
    
    
	
	
	
		
		
	



	
Education
	
	

	
PhD in Biochemistry, University of California, Berkeley
        

              
   
  
 
 	
Research Summary
	
	

	
Our research is directed toward elucidating the roles and
regulation of the arginases in diseases such as asthma, sickle cell
disease, hypertension, atherosclerosis, and diabetic nephropathy. As
part of studies to determine the mechanism of action of the arginases
in these diseases, we are investigating the signal transduction
pathways, DNA elements and transcription factors involved in regulating
expression of the arginase genes in response to cytokines and other
agents that play key roles in the disease processes. Our long-term goal
is to identify new targets for therapeutic intervention in disease.
	
	




  
 
 
 
 
 
 
 
         
        
        
        
        
        
        
        
        
 
 
   
   
















        





















	
Publications
	
	

	
Sheldon, KE; Shandilya, H; Kepka-Lenhart, D; Poljakovic, M; Ghosh, A. and Morris, S.M., Jr. (2013) Shaping the murine macrophage phenotype: IL-4 and cyclic AMP synergistically activate the arginase I promoter. J Immunol. [Epub date 08/02/2013] |  View Abstract
You, H; Gao, T; Cooper, T. K; Morris, S. M., Jr. and Awad, A. S. (2013) Arginase inhibition mediates renal tissue protection in diabetic nephropathy by a nitric oxide synthase 3-dependent mechanism. Kidney Int. [Epub date 06/14/2013] |  View Abstract
Mattila, J. T; Ojo, O. O; Kepka-Lenhart, D; Marino, S; Kim, J. H; Eum, S. Y; Via, L. E; Barry, C. E., 3rd; Klein, E; Kirschner, D. E; Morris, S. M., Jr.; Lin, P. L. and Flynn, J. L. (2013) Microenvironments in Tuberculous Granulomas Are Delineated by Distinct Populations of Macrophage Subsets and Expression of Nitric Oxide Synthase and Arginase Isoforms. J Immunol. 191: 773-784. |  View Abstract
Morris, S. M., Jr. (2012) Arginases and arginine deficiency syndromes. Curr Opin Clin Nutr Metab Care. 15: 64-70. |  View Abstract
Morris, S. M., Jr; Gao, T; Cooper, T. K; Kepka-Lenhart, D; and Awad, A. S. (2011) Arginase-2 mediates diabetic renal injury. Diabetes. 60: 3015-3022. |  View Abstract
Sharda, D. R; Yu, S; Ray, M; Squadrito, M. L; De Palma, M; Wynn, T. A; Morris, S. M., Jr; and Hankey, P. A. (2011) Regulation of macrophage arginase expression and tumor growth by the Ron receptor tyrosine kinase. J. Immunol 187: 2181-2192. |  View Abstract
Morris, S. M., Jr. (2009) Recent advances in arginine metabolism: roles and regulation of the arginases. Br J Pharmacol. 157: 922-930. |  View Abstract