University of Pittsburgh

Lucia Mazzacurati, PhD

Postdoctoral Associate





	
	


			

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Contact

    		

		lum1@pitt.edu	
		

		
		
	
	
	    

    
    
   
    
   
    
        
    
   
   
   
   
   
   
    
    
	
	
	
		
		
	



	
Education
	
	

	
PhD in Human Genetics, University of Pittsburgh, Graduate School of Public Health, 2012
Honor Degree (equal to BSc+MSc) in Biotechnology, University of Bologna (Italy)
        

              
   
  
 
 


  
 
 
 
 
 	
Program
	
	

	Human Genetics (GSPH)	
	


 
 
 	
Mentor
	
	

	
Paola Grandi, PhD
        

                
        
        
        
        	
Dissertation
	
	

	Development of a New Class of Microrna Controlled OHSV Vectors for Treatment of Glioblastoma	
	


        
        
        
        
 
 
   
   
















        













	
Areas of Interest
	
	

	Virology, Oncology	
	






	
Why I Chose Pitt
	
	

	
I found my graduate school program very interesting. Also
University of Pittsburgh is a very good place to do high quality research.
Following her graduation, Lucia accepted a postdoctoral associate position in the Department of Pathology here at the University of Pittsburgh.
Abstracts
Mazzacurati L, Marzulli M, Reinhart B, Cohen JB, Glorisos JC, Grandi P. MicroRNA Control of HSV-1 Replication for the Treatment of Glioblastoma Multiforme. ASGCT 2011 Annual Meeting
	
	




	
Publications
	
	

	
A nuclear role for Kaposi's sarcoma-associated herpesvirus-encoded K13 protein in gene regulation. Oncogene. 27: 5243-5253. |  View Abstract
K13 blocks KSHV lytic replication and deregulates vIL6 and hIL6 expression: a model of lytic replication induced clonal selection in viral oncogenesis. PLoS One. 2: e1067. |  View Abstract
Induction of spindle cell morphology in human vascular endothelial cells by human herpesvirus 8-encoded viral FLICE inhibitory protein K13. Oncogene. 26: 1656-1660. |  View Abstract
Kaposi's sarcoma-associated herpesvirus (KSHV) oncoprotein K13 bypasses TRAFs and directly interacts with the IkappaB kinase complex to selectively activate NF-kappaB without JNK activation. J. Biol. Chem. 282: 24858-24865. |  View Abstract
Endoplasmic reticulum stress initiates apoptotic death induced by STI571 inhibition of p210 bcr-abl tyrosine kinase. Leuk. Res. 28: 191-202. |  View Abstract
Chk2 drives late G1/early S phase arrest of clonal myeloid progenitors expressing the p210 BCR-ABL tyrosine kinase in response to STI571. Hematol. J. 5: 168-177. |  View Abstract
The p210BCR-ABL tyrosine kinase of chronic myeloid leukemia causes resistance to radio-induced apoptotic death by inhibiting the proapoptotic BAX gene. Leukemia. 18: 370-372. |  View Abstract