University of Pittsburgh

JoAnne L. Flynn, PhD

Distinguished Professor





	
	


			

		Dr. JoAnne Flynn	
		

		

	
Contact

    		

		joanne@pitt.edu	
		

		
			

		412-624-7743	
		

		
	
	
	    

    
    
   
    
   
    
    		

		
5058 Biomedical Science Tower 3
3501 Fifth Avenue
	
		

	    
    
   
   
   
   
   
   
    
    
	
	
	
			

		Pittsburgh, PA 15260	
		

		
		
	



	
Education
	
	

	
Postdoc, Albert Einstein College of Medicine
Postdoc, Research Institute of Scripps Clinic
PhD in Microbial Genetics/Pathogenic Mechanisms, University of California, Berkeley
BS in Biochemistry, University of California, Davis
        

              
   
  
 
 	
Research Summary
	
	

	
Our lab focuses on tuberculosis. We study host-pathogen interactions, immunology of tuberculosis, vaccines and drugs. We developed and use non-human primate models of tuberculosis for all our work. We also study HIV/M. tuberculosis co-infections in non-human primate models.
Click here for a full listing of publications
	
	




  
 
 
 
 
 
 
 
         
        
        
        
        
        
        
        
        
 
 
   
   
















        









	
Research Lab Affiliation
	
	

	Flynn Lab	
	













	
Publications
	
	

	
Gideon HP*, Hughes TK*, Tzouanas CN*, Wadsworth MH, Tu AA, Gierahn TM, Peters JM, Hopkins FF, Wei J-R, Kummerlowe C, Grant NL, Nargan K, Phuah JY, Borish HJ, Maiello P, White AG, Winchell CG, Nyquist SK, Ganchua SKC, Myers A, Patel KV, Ameel CL, Cochran CT, Ibrahim S, Tomko JA, Frye LJ, Rosenberg JM, Shih A, Chao M, Klein E, Scanga CA, Ordovas-Montanes J, Berger B, Mattila JT, Madansein R, Love JC, Lin PL, Leslie A, Behar SM, Bryson B, Flynn JL#, Fortune SM#, Shalek AK#. Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control. Immunity 2022 May 10;55(5):827-846.e10. doi: 10.1016/j.immuni.2022.04.004. Epub 2022 Apr 27. *co-first authors; # co-senior authors |  View Abstract
Grant NL, Maiello P, Klein E, Lin PL, Borish HJ, Tomko J, Frye LJ, White AG, Kirschner DE, Mattila JT, Flynn JL. T cell transcription factor expression evolves over time in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques. Cell Reports 39:7, p.110826, May 17, 2022. https://doi.org/10.1016/j.celrep.2022.110826. |  View Abstract
Darrah PA, Zeppa JJ, Maiello P, Hackney JA, Wadsworth MH, Hughes TK, Pokkali S, Swanson PA, Grant NL, Rodgers MA, Kamath M, Causgrove CM, Laddy DJ, Bonavia A, Casimiro D, Lin PL, Klein E, White AG, Scanga CA, Shalek AK, Roederer M*, Flynn JL*, Seder RA*. Prevention of tuberculosis in nonhuman primates following intravenous BCG immunization. Nature, 2020. Jan; 577(7788): 95-102. Epub 2020 Jan 1.  |  View Abstract
Cadena AM, Hopkins FF, Maiello P, Carey AF, Wong EA, Martin CJ, Gideon HP, DiFazio RM, Andersen P, Lin PL, Fortune SM, Flynn JL. Concurrent infection with Mycobacterium tuberculosis confers robust protection against secondary infection in macaques. PLoS Pathog. 2018 Oct 12; 14(10):e1007305. doi: 10.1371/journal.ppat.1007305. eCollection 2018 Oct. |  View Abstract
Ganchua SKC, Cadena AM, Maiello P, Gideon HP, Myers AJ, Junecko BF, Klein EC, Lin PL, Mattila JT, Flynn JL. Lymph nodes are sites of prolonged bacterial persistence during Mycobacterium tuberculosis infection in macaques. PLoS Pathog. 2018 Nov 1;14(11):e1007337. doi: 10.1371/journal.ppat.1007337. eCollection 2018 Nov.  |  View Abstract