University of Pittsburgh

Masahiro Shuda, PhD

Assistant Professor





	
	


			

		Dr. Masa Shuda	
		

		

	
Contact

    		

		mas253@pitt.edu	
		

		
			

		412-623-7733	
		

		
	
	
			

		Fax: 
		412-623-7715	
		

	    

    
    
   
    
   
    
    		

		
1.9 Hillman Cancer Center
5117 Centre Avenue
	
		

	    
    
   
   
   
   
   
   
    
    
	
	
	
			

		Pittsburgh, PA 15213	
		

		
		
	



	
Education
	
	

	
PhD in Molecular Virology, Tokyo Medical and Dental University
BS in Health Science, Tokyo Medical and Dental University
        

              
   
  
 
 	
Research Summary
	
	

	
Tumor virus research has provided a wealth of information for cancer biology. Polyomaviruses
in particular have been central to understanding basic mechanisms of cancer cell transformation. Studies on the SV40 T antigen, for example, led to the discovery of p53 and uncovered the functions of retinoblastoma tumor suppressor protein in cell cycle regulation. Research on murine polyomavirus led to the discovery of tyrosine phosphorylation and the phosphoinositide 3-kinase signaling pathway. Each new cancer virus provides a new model for investigating basic pathways in carcinogenesis. My research exploits the most recently discovered human tumor virus, Merkel cell polyomavirus (MCV), to identify novel cellular pathways leading to cancer.
	
	




  
 
 
 
 
 
 
 
         
        
        
        
        
        
        
        
        
 
 
   
   
















        









	
Research Lab Affiliation
	
	

	Moore Lab	
	













	
Publications
	
	

	
Guastafierro, A; Feng, H; Thant, M; Kirkwood, J. M; Chang, Y; Moore, P. S. and Shuda M. (2012) Characterization of an early passage Merkel cell polyomavirus-positive Merkel cell carcinoma cell line, MS-1, and its growth in NOD scid gamma mice. J Virol Methods. 187: 6-14. |  View Abstract
Arora, R; Shuda, M; Guastafierro, A; Feng, H; Toptan, T; Tolstov, Y; Normolle, D; Vollmer, L. L; Vogt, A; Domling, A; Brodsky, J. L; Chang Y. and Moore P. S. (2012) Survivin is a therapeutic target in Merkel cell carcinoma. Sci Transl Med. 133: 133ra56. |  View Abstract
Shuda, M; Kwun, H. J; Feng, H; Chang, Y; and Moore, P. S. (2011) Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator. J Clin Invest. 121: 3623-3634. |  View Abstract
Houben, R; Shuda, M; Weinkam, R; Schrama, D; Feng, H; Chang, Y; Moore, P. S. and Becker, J. C. (2010) Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens. J Virol. 84: 7064-7072. |  View Abstract
Shuda, M; Arora, R; Kwun, H. J; Feng, H; Sarid, R; Fernandez-Figueras, M. T; Tolstov, Y; Gjoerup, O; Mansukhani, M. M; Swerdlow, S. H; Chaudhary, P. M; Kirkwood, J. M; Nalesnik, M. A; Kant, J. A; Weiss, L. M; Moore, P. S. and Chang, Y. (2009) Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors. Int. J Cancer. 125: 1243-1249. |  View Abstract
Shuda, M; Feng, H; Kwun, H. J; Rosen, S. T; Gjoerup, O; Moore, P. S; and Chang, Y. (2008) T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus. Proc Natl Acad Sci USA. 105: 16272-16277. |  View Abstract
Feng, H; Shuda, M; Chang, Y; and Moore, P. S. (2008) Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science. 319: 1096-1100. |  View Abstract