Joseph C. Glorioso III, PhD
Professor
428 Bridgeside Point II
450 Technology Drive
Education
PhD in Microbiology, Louisiana State University
Research Summary
Dr. Glorioso has established a
35-year history of research related to the basic biology and genetics of herpes
simplex virus. His contributions to the field include defining antiviral immune
responses to infection, the genetics of viral pathogenesis and latency, and
mechanisms of viral infection. Furthermore, he has been a pioneer in the design
and application of HSV gene vectors for the treatment of nervous system
diseases such as peripheral neuropathies, chronic pain, and brain tumors. He
continues to be a worldwide leader in the HSV gene vector field through the
creation of innovative gene vectors and the development of manufacturing
methods for Phase I and Phase II human clinical trials for pain gene therapy.
His enkephalin vector showed considerable promise in a Phase I human trial to
treat cancer pain and phase II testing is underway. These trials were sponsored
by Diamyd Medical AB in Stockholm. Dr. Glorioso is a Diamyd stockholder.
Dr. Glorioso’s most recent research has focused on (i) the design and
application of HSV gene vectors for exploring the molecular events that occur
in sensory afferents that are involved in the transition from acute to chronic
pain, (ii) the development of retargeted oncolytic HSV vectors for specific
infection and replication in human glioblastomas and applications to treatment
of xenograft models of human brain human brain tumors, (iii) the creation of
novel HSV vectors that cross the blood brain barrier by transcytosis followed
targeted infection and gene expression in spiny neurons of the striatum; these
vectors are being applied to treatment of animal models of Huntington’s disease
and (iv) the use of HSV gene vectors for the creation of induced pluripotent
stem (iPS) cells and the identification of transcriptional regulatory and
signaling processes that participate in cellular reprogramming.
Research Lab Affiliation
Publications
Niedernhofer, L. J; Glorioso, J. C; and Robbins, P. D. (2011) Dedifferentiation rescues senescence of progeria cells but only while pluripotent. Stem Cell Res Ther. 2: 28. | View Abstract
Dmitrieva, N; Yu, L; Viapiano, M; Cripe, T. P; Chiocca, E. A; Glorioso, J. C; and Kaur, B. (2011) Chondroitinase ABC I-mediated enhancement of oncolytic virus spread and antitumor efficacy. Clin Cancer Res. 17: 1362-1372. | View Abstract
Fink, D. J; Wechuck, J; Mata, M; Glorioso, J. C; Goss, J; Krisky, D; and Wolfe, D. (2011) Gene therapy for pain: results of a phase I clinical trial. Ann Neurol. 70: 207-212. | View Abstract
Goss, J. R; Cascio, M; Goins, W. F; Huang, S; Krisky, D. M; Clarke, R. J; Johnson, J. W; Yokoyama, H; Yoshimura, N; Gold, M. S; and Glorioso, J. C. (2011) HSV Delivery of a Ligand-regulated Endogenous Ion Channel Gene to Sensory Neurons Results in Pain Control Following Channel Activation. Mol Ther. 19: 500-506. | View Abstract
Uchida, H; Chan, J; Goins, W. F; Grandi, P; Kumagai, I; Cohen, J. B; and Glorioso, J. C. (2010) A double mutation in glycoprotein gB compensates for ineffective gD-dependent initiation of herpes simplex virus type 1 infection. J Virol. 84: 12200-12209. | View Abstract
Goss, J. R; Gold, M. S; and Glorioso, J. C. (2009) HSV vector-mediated modification of primary nociceptor afferents: an approach to inhibit chronic pain. Gene Ther. 16: 493-501. | View Abstract
Wolfe, D; Craft, A. M; Cohen, J. B; and Glorioso, J. C. (2010) A herpes simplex virus vector system for expression of complex cellular cDNA libraries. J Virol. 84: 7360-7368. | View Abstract