University of Pittsburgh

Jihong Li, PhD

Research Instructor





	
	


			

		Dr. Li	
		

		

	
Contact

    		

		jihongli@pitt.edu	
		

		
			

		412-648-9021	
		

		
	
	
			

		Fax: 
		412-624-1401	
		

	    

    
    
   
    
   
    
    		

		
447 Bridgeside Point II
450 Technology Drive
	
		

	    
    
   
   
   
   
   
   
    
    
	
	
	
			

		Pittsburgh, PA 15219-3143	
		

		
		
	



	
Education
	
	

	
PhD in Molecular Biology, South China University of Tropical Agriculture, Hainan (P.R. China)
        

              
   
  
 
 	
Research Summary
	
	

	
Dr. Li has conducted research on the
pathogenesis of C. perfringens
diseases originating in the intestines since 2005. During these six years, she
completed one four-year USDA grant (Molecular Epidemiology of CPE-Associated
Food Poisoning, January 1, 2005 to December 31, 2008) and also worked on two
other on-going NIH grants (The Mechanism of Action of Clostridium perfringens enterotoxin and Virulence Plasmids of Clostridium perfringens type B-D). Now
she is working on a MARCE grant to study the action of epsilon toxin, a class B
select toxin. Her work has produced 19 publications on C. perfringens, of which ten involve first authorship. 
	
	




  
 
 
 
 
 
 
 
         
        
        
        
        
        
        
        
        
 
 
   
   
















        









	
Research Lab Affiliation
	
	

	McClane Lab	
	













	
Publications
	
	

	
Li, J; Chen, J; Vidal, J. E; and McClane, B. A. (2011) The Agr-like quorum-sensing system regulates sporulation and production of enterotoxin and beta2 toxin by Clostridium perfringens type A non-food-borne human gastrointestinal disease strain F5603. Infect Immun. 79: 2451-2459. |  View Abstract
Li, J; and McClane, B. A. (2010) Evaluating the involvement of alternative sigma factors SigF and SigG in Clostridium perfringens sporulation and enterotoxin synthesis. Infect Immun. 78: 4286-4293.  |  View Abstract
Li, J; Miyamoto, K; Sayeed, S; and McClane, B. A. (2010) Organization of the cpe locus in CPE-positive clostridium perfringens type C and D isolates. PLoS One. 5: e10932. |  View Abstract
Li, J; Paredes-Sabja, D; Sarker, M. R; and McClane, B. A. (2009) Further characterization of Clostridium perfringens small acid soluble protein-4 (Ssp4) properties and expression. PLoS One. 4: e6249. |  View Abstract
Li, J; and McClane, B. A. (2008) A novel small acid soluble protein variant is important for spore resistance of most Clostridium perfringens food poisoning isolates. PLoS Pathog. 4: e1000056. |  View Abstract
Li, J; Miyamoto, K; and McClane, B. A. (2007) Comparison of virulence plasmids among Clostridium perfringens type E isolates. Infect Immun. 75: 1811-1819. |  View Abstract
Li, J; and McClane, B. A. (2006) Comparative effects of osmotic, sodium nitrite-induced, and pH-induced stress on growth and survival of Clostridium perfringens type A isolates carrying chromosomal or plasmid-borne enterotoxin genes. Appl Environ Microbiol. 72: 7620-7625. |  View Abstract